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Healthcare professional holding hands with a patient in a caring way while receiving dialysis
Healthcare professional holding hands with a patient in a caring way while receiving dialysis.

Expanded Hemodialysis (HD)

Expanded HD is a type of hemodialysis that uses a special filter, called a dialyzer. It cleans your blood better than regular hemodialysis. This filter can remove larger waste products from your blood. These larger waste products are called "middle molecules." Removing more waste may support your overall health and may help you feel better too. Expanded HD will look and feel much like the dialysis you get today.

If you would like to learn more about Expanded HD, download this educational flier brought to you by the National Kidney Foundation (NKF) and the ÑÇÖÞÎÞÂë Giving Foundation.

What are "middle molecules" and why do they matter?Ìý

Middle molecules are larger waste products thatÌýcanÌýbuild up inÌýyourÌýblood when your kidneys areÌýnotÌýworkingÌýwell.ÌýIf theseÌýwaste productsÌýare not removed, theyÌýmayÌýcauseÌýswelling or irritation in theÌýbodyÌýÌýthatÌýcan worsen otherÌýhealth issues. They may also be linkedÌýto symptoms likeÌýfeeling tired, joint pain, andÌýitchy skin.Ìý

How is Expanded HD different from conventional hemodialysis?Ìý

TheÌýonlyÌýdifference is the filter. Expanded HD uses an advancedÌýfilter that can removeÌýlarger waste products. RegularÌýfiltersÌýmayÌýmissÌýsome of this larger waste.ÌýThis new, advanced filter fits into the same machines and uses the same treatmentÌýsteps as regular filters. So, the treatmentÌýand care from your teamÌýwillÌýlookÌýand feelÌýthe same.Ìý

How might Expanded HD change how I feel?Ìý

BecauseÌýExpanded HDÌýremoves moreÌýwaste, someÌýpatientsÌýsayÌýthey feelÌýbetterÌýdayÌýtoÌýday.ÌýBenefits mayÌýinclude:Ìý

-Feeling less tired after dialysisÌý
-Sleeping betterÌý
-Less itchy skinÌýand/or restless legsÌý

Is Expanded HD safe?Ìý

Yes. Expanded HD uses advanced filters that have been studiedÌýin many countries. These filters areÌýFDA approved. Studies show Expanded HD isÌýa safe and effective way to cleanÌýmore waste from theÌýblood.Ìý

How areÌýExpanded HDÌýand HDFÌýdifferent?Ìý

Expanded HD and HDF areÌýbothÌýadvanced dialysis options.ÌýHD means hemodialysis. HDF means hemodiafiltration.ÌýÌý

Both helpÌýremoveÌýlargerÌýwaste products, called “middleÌýmolecules,â€� from the blood. This mayÌýhelp you feel better andÌýsupportÌýyour overall health. The main difference is howÌýeach treatmentÌýremovesÌýwaste.Ìý

Expanded HDÌýuses anÌýadvanced filter that works withÌýtheÌýdialysisÌýmachineÌýand process you are used to.ÌýHDF needs special dialysis machines, extra replacement fluid, and sometimes higher blood flow during treatment.ÌýResearchÌýshowsÌýbothÌýoptions mayÌýoffer similarÌýhealthÌýbenefits and symptom relief.ÌýExpanded HD may be easier to offer to more patients because it does not need special machines,Ìýlots of fluid,Ìýor changes to blood flow.

Are you a medical professional? Read ourÌýclinical breakdown of Middle Molecule Clearance.

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