What are "middle molecules" and why do they matter?Ìý Middle molecules are larger waste products thatÌýcanÌýbuild up inÌýyourÌýblood when your kidneys areÌýnotÌýworkingÌýwell.ÌýIf theseÌýwaste productsÌýare not removed, theyÌýmayÌýcauseÌýswelling or irritation in theÌýbodyÌýÌýthatÌýcan worsen otherÌýhealth issues. They may also be linkedÌýto symptoms likeÌýfeeling tired, joint pain, andÌýitchy skin.Ìý
How is Expanded HD different from conventional hemodialysis?Ìý TheÌýonlyÌýdifference is the filter. Expanded HD uses an advancedÌýfilter that can removeÌýlarger waste products. RegularÌýfiltersÌýmayÌýmissÌýsome of this larger waste.ÌýThis new, advanced filter fits into the same machines and uses the same treatmentÌýsteps as regular filters. So, the treatmentÌýand care from your teamÌýwillÌýlookÌýand feelÌýthe same.Ìý
How might Expanded HD change how I feel?Ìý BecauseÌýExpanded HDÌýremoves moreÌýwaste, someÌýpatientsÌýsayÌýthey feelÌýbetterÌýdayÌýtoÌýday.ÌýBenefits mayÌýinclude:Ìý
-Feeling less tired after dialysisÌý
-Sleeping betterÌý
-Less itchy skinÌýand/or restless legsÌý
Is Expanded HD safe?Ìý Yes. Expanded HD uses advanced filters that have been studiedÌýin many countries. These filters areÌýFDA approved. Studies show Expanded HD isÌýa safe and effective way to cleanÌýmore waste from theÌýblood.Ìý
How areÌýExpanded HDÌýand HDFÌýdifferent?Ìý Expanded HD and HDF areÌýbothÌýadvanced dialysis options.ÌýHD means hemodialysis. HDF means hemodiafiltration.ÌýÌý
Both helpÌýremoveÌýlargerÌýwaste products, called “middleÌýmolecules,â€� from the blood. This mayÌýhelp you feel better andÌýsupportÌýyour overall health. The main difference is howÌýeach treatmentÌýremovesÌýwaste.Ìý
Expanded HDÌýuses anÌýadvanced filter that works withÌýtheÌýdialysisÌýmachineÌýand process you are used to.ÌýHDF needs special dialysis machines, extra replacement fluid, and sometimes higher blood flow during treatment.ÌýResearchÌýshowsÌýbothÌýoptions mayÌýoffer similarÌýhealthÌýbenefits and symptom relief.ÌýExpanded HD may be easier to offer to more patients because it does not need special machines,Ìýlots of fluid,Ìýor changes to blood flow.